Rules for preparation and reception
According to the instructions, the suspension for children "Augmentin 400" should be prepared independently from the powder purchased in a pharmacy in the same bottle. Buy augmentin becouse the volume of the container in which the antibiotic itself is located is designed to add water in an amount needed to dilute the drug to any concentration. So, to prepare a suspension with a dosage of 125 mg per 5 ml, add 60 ml of chilled boiled water to the vial, close the lid and shake the contents thoroughly until the powder is completely dissolved. After that, more water is added to the container so that the total volume of the suspension is 92 ml.
If it is necessary to dose the Augmentin suspension 400 mg per one scoop, first pour 40 ml of liquid into the vial and also thoroughly mix all contents by shaking for several minutes. After that, the total volume of the drug is increased to 64 ml by adding more water.
After dilution, the drug should only be stored in the refrigerator..
Before each use, the vial should be shaken thoroughly, and only then measure the desired dosage. This is due to the fact that the suspension is stratified during storage. Correctly dosing the drug helps with a measured cap, which is sold along with each bottle of medication. After taking the medicine, the measuring container must be thoroughly washed..
Infants are given a suspension during feeding, and older babies before a meal to reduce the risk of gastric and intestinal disorders, as well as increase the absorption of the active substance.
For children under 2 years old, a measured dose of the suspension is allowed to be additionally diluted with water 1: 1 to facilitate swallowing.
The dosage of the Augmentin 400 suspension for children depends on the diagnosis, its severity, the baby’s weight, his age and the state of the kidneys. The minimum course of therapy is 5 days. If necessary, the duration of the medication can be increased, but not more than 14 days, since then the antibiotic will begin to have an adverse effect on the body.
Both active substances amoxicillin and clavulanic acid are rapidly and completely absorbed from the gastrointestinal tract (GIT) after oral administration. Absorption of the active substances of the drug Amoxicillin + Clavulanic acid-Vial is optimal if the drug is taken at the beginning of a meal. The maximum concentration of amoxicillin and clavulanic acid in blood plasma (C max ) is achieved after 0.9-1.5 hours after taking the drug. WITHmax amoxicillin and clavulanic acid when taking the drug at a dose of 250 mg + 125 mg is 3.7 mg / l and 2.2 mg / l, respectively. When taking the drug at a dose of 500 mg + 125 mg, these indicators were 6.5 mg / l and 2.8 mg / l, respectively.
Amoxicillin and clavulanic acid have a weak degree of binding to plasma proteins. Studies have shown that about 25% of the total amount of clavulanic acid and 18% of amoxicillin binds to blood plasma proteins. Therapeutic concentrations are found in body fluids and tissues (lungs, pleural, peritoneal, synovial fluids, bronchial secretions, muscle tissue, adipose tissue, gall bladder, abdominal tissues, skin, purulent discharge). Amoxicillin, like most penicillins, passes into breast milk. Traces of clavulanic acid have also been found in breast milk. With the exception of the possibility of sensitization, diarrhea, or candidiasis of the oral mucous membranes, no other negative effects of amoxicillin and clavulanic acid on the health of breast-fed infants are known. In experimental studies, it was found that amoxicillin and clavulanic acid cross the placental barrier. However, no adverse effects on the fetus were detected..
10-25% of the initial dose of amoxicillin is excreted by the kidneys in the form of an inactive metabolite (penicilloic acid). Clavulanic acid in the human body is extensively metabolized to 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1H-pyrrole-3-carboxylic acid and 1-amino-4-hydroxy-butan-2-one and excreted by the kidneys, intestines and with exhaled air
Like other penicillins, amoxicillin is excreted mainly by the kidneys, while clavulanic acid through both the renal and extrarenal mechanisms. About 60-70% of amoxicillin and about 40-65% of clavulanic acid are excreted by the kidneys unchanged in the first 6 hours after applying 1 tablet of 250 mg / 125 mg or 500 mg / 125 mg. The half-life (T½) amoxicillin is 1.0 and 1.3 hours, respectively, and clavulanic acid is 1.2 and 0.8 hours, respectively.
International name: Ticarcillin + Clavulanic acid (Ticarcillin + Clavulanic acid)
Dosage form: lyophilisate for solution for infusion
Pharmacological action: Timentin is a combined drug whose action is due to the components that make up its composition. Ticarcillin - an antibacterial agent .
Indications: Bronchitis, pneumonia, urinary tract infections, abdominal infections, infections of the pelvic organs, skin and soft tissues, bones and joints, .
With a course of treatment, it is necessary to monitor the state of the function of the blood, liver and kidneys.
In order to reduce the risk of side effects from the gastrointestinal tract, the drug should be taken with meals.
It is possible to develop superinfection due to the growth of microflora insensitive to it, which requires a corresponding change in antibiotic therapy.
May give false positive results in the determination of glucose in the urine. http://www.richmondent.com/sinus-allergy/sinusitis/sinus-treatments/antibiotics-and-sinusitis/ In this case, it is recommended to use the glucose oxidant method for determining the concentration of glucose in the urine..
After dilution, the suspension should be stored for no more than 7 days in the refrigerator, but do not freeze..
In patients with hypersensitivity to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.
Cases of necrotizing colitis in newborns and in pregnant women with premature rupture of membranes were identified.
Since the tablets contain the same amount of clavulanic acid (125 mg), it should be borne in mind that 2 tablets of 250 mg (for amoxicillin) are not equivalent to 1 tablet for 500 mg (for amoxicillin).